Transfusion guidelines for both study groups were developed from information obtained in a national survey of critical care practitioners in Canada 13 and a pilot study. 14 The hemoglobin The New England Journal of Medicine transfusion Platelet Transfusion Guidelines Lise J. Estcourt. Today's topics •Prophylaxis Transfusion Audited episodes in each category Appropriate Indeterminate Outside guidelines NEJM 2013 al 2012 . Lancet. Platelet Tx Guidelines • ASCO Clinical Practice Guideline, 2001 • C17 adapted to ped Heme/Onc, 2011 -Prophylactic transfusion recommended •Except if chronic alloimmune thrombocytopenia • Triggers apply only to stable patients Wandt et al, Lancet, 2012;380:1209-16 NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and insightful commentary A recent review describes the diagnosis, treatment, and prevention of the various types of transfusion reactions. Most common are febrile Transfusion Current guidelines from the European Union and United States recommend a transfusion trigger of of 10 ? 109/l for platelets transfused prophylactically. These guidelines are based on outcomes from four randomized clinical trials that compared prophylactic triggers of 10 ? 109/l versus 20 ? 109/l in patients with Recent guidelines recommended a restrictive strategy (transfusion when the hemoglobin level is less than 7 g/dL) for adult trauma and critical care patients, with the exception of those with acute myocardial ischemia . Furthermore, these guidelines recommended avoiding transfusion based only on a hemoglobin trigger. Massive Transfusion in TrauMa GuIdelIneS. the following guidelines is to identify the necessary components of an MTP and address key issues involved in developing an MTP for trauma. Development of a Massive Transfusion Protocol: Engagement NEJM Journal Watch reviews over 250 scientific and medical journals to present important clinical research findings and i