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Prior to first use, BYETTA (exenatide injection) must be stored refrigerated at See the Pen User Manual that comes with BYETTA for instructions for using the With its newly approved label, Eli Lilly and Amylin Pharmaceuticals' Byetta no longer requires refrigeration after the first use. Type 2 diabetes patients can now Find important dosing, administration, and storage information for the BYETTA BYETTA offers optional 1-step titration; How to prescribe; Instructions for use Store your unused BYETTA Pen in the original carton in a refrigerator at 36°F to 46°F (2°C to 8°C) protected from light. Do not freeze. Throw away any BYETTA Pen that has been frozen. After first use, your BYETTA Pen should be refrigerated or kept cold 36°F to 46°F (2°C to 8°C) when not in use. 20 Feb 2007 Patients can now keep a BYETTA Pen at a temperature anywhere from 36 degrees F (2 degrees C) to 77 degrees F (25 degrees C) after first use. Until first use, BYETTA Pens must continue to be stored in a refrigerator between 36 degrees F (2 degrees C) and 46 degrees F (8 degrees C). Byetta comes in a prefilled injection pen with a "Pen User Manual" showing Storing opened (in use) Byetta: Store at room temperature and use within 30 days.How to store and handle BYETTA. Important notes See the Pen User Manual that comes with BYETTA for instructions for using the Pen and injecting BYETTA. 27 Feb 2007 As reported in last week newsletter, it is no longer necessary to refrigerate the Byetta pen after you begin to use it, which will increase Byetta Solution for injection is a brand of medicine containing the active Read the User Manual for information on how to use the pen before beginning therapy. . Storage. Keep your unopened BYETTA pen in the refrigerator where the instructions completely may result in a wrong dose, a broken pen or an infection. These instructions do Do not store the Byetta pen with the needle attached.